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Ozonated oils as functional dermatological matrices: effects on the wound healing process using SKH1 mice.

Abstract
Wound tissue repair is a complex and dynamic process of restoring cellular structures and tissue layers. Improvement of this process is crucial for several pathologies characterized by chronic delayed wound closure such as diabetes, and the investigation of new approaches aimed to ameliorate the wound healing process is under continuous evolution. Recently, the usage of vegetable matrices in the form of ozonated oils has been proposed and several researchers have shown a positive effect in the wound, based on their bactericidal, antiviral, and antifungal properties. The present study was undertaken to compare the effect that different ozonated oils (olive, sesame and linseed) with the same level of ozonation have on wound healing rate in SKH1 mice. Several histological parameters and the level of key proteins such as VEGF and PCNA have been analyzed. Only treatment with ozonated sesame oil shows a faster wound closure in the first 7 days. This effect paralleled with the increased VEGF and PCNA levels, NFκB nuclear translocation and 4-HNE formation. The present study shows that not only the ozonation grade is of importance for the improvement of wound healing process but also the typical composition of the oil.
AuthorsG Valacchi, I Zanardi, Y Lim, G Belmonte, C Miracco, C Sticozzi, V Bocci, V Travagli
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 458 Issue 1 Pg. 65-73 (Dec 15 2013) ISSN: 1873-3476 [Electronic] Netherlands
PMID24144953 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • NF-kappa B
  • Plant Oils
  • Proliferating Cell Nuclear Antigen
  • Vascular Endothelial Growth Factor A
  • Collagen
Topics
  • Animals
  • Collagen (metabolism)
  • Female
  • Mice
  • NF-kappa B (metabolism)
  • Plant Oils (pharmacology)
  • Proliferating Cell Nuclear Antigen (metabolism)
  • Skin (drug effects, metabolism)
  • Vascular Endothelial Growth Factor A (metabolism)
  • Wound Healing (drug effects)

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