Abstract |
Experiments on albino outbred rats showed that chronic poisoning with organophosphorus compounds ( Russian VX, and sarin) for 30 days in a total dose of 0.3 DL50 (0.01 DL50 daily) is followed by a decrease in phagocytic and metabolic activity of neutrophils. The reduction of functional activity of monocyte phagocytic system was stipulated by the stimulation of N- cholinergic receptors of these cells. These changes were accompanied by a decrease in blood concentration of proinflammatory cytokines (TNF-α, IL-1β, and IL-6).
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Authors | P F Zabrodskii, V A Grishin, V K Borodavko |
Journal | Bulletin of experimental biology and medicine
(Bull Exp Biol Med)
Vol. 155
Issue 4
Pg. 464-6
(Aug 2013)
ISSN: 1573-8221 [Electronic] United States |
PMID | 24143369
(Publication Type: Journal Article)
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Chemical References |
- Cholinesterase Inhibitors
- Cytokines
- Inflammation Mediators
- Nicotinic Agonists
- Organothiophosphorus Compounds
- Nicotine
- Sarin
- S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate
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Topics |
- Animals
- Animals, Outbred Strains
- Cholinesterase Inhibitors
(toxicity)
- Cytokines
(metabolism)
- Female
- Inflammation Mediators
- Lethal Dose 50
- Male
- Neutrophils
(drug effects, physiology)
- Nicotine
(toxicity)
- Nicotinic Agonists
(toxicity)
- Organothiophosphorus Compounds
(toxicity)
- Phagocytosis
(drug effects)
- Rats
- Sarin
(toxicity)
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