Use of acute phase protein changes to assess the effects of a nonsteroidal antiinflammatory drug (niflumic acid) on the inflammation process induced by limited plastic surgery.

Abstract	Serum levels of acute phase proteins (C-reactive protein, alpha 1 acid glycoprotein, and haptoglobin) have been measured to assess the effects of a nonsteroidal antiinflammatory drug (niflumic acid). Thirty patients undergoing plastic surgery have been studied. The results obtained from this surgical model prove that nonsteroidal antiinflammatory drugs can modify acute phase response and especially acute phase proteins levels. The participation of prostaglandins in the acute phase protein variations is discussed. The authors conclude that haptoglobin could provide a convenient tool for studying some aspects of prostaglandin action in vivo.
Authors	J Bienvenu, P Laurent, L F Perrin, B Colin, J P Rebattu
Journal	International journal of clinical pharmacology research (Int J Clin Pharmacol Res) Vol. 5 Issue 4 Pg. 269-72 ( 1985) ISSN: 0251-1649 [Print] Switzerland
PMID	2414236 (Publication Type: Journal Article)
Chemical References	Acute-Phase Proteins Blood Proteins Haptoglobins Nicotinic Acids Orosomucoid Niflumic Acid C-Reactive Protein
Topics	Acute-Phase Proteins Adolescent Adult Blood Proteins (analysis) C-Reactive Protein (analysis) Edema (blood, drug therapy, etiology) Female Haptoglobins (analysis) Humans Male Nicotinic Acids (therapeutic use) Niflumic Acid (therapeutic use) Orosomucoid (analysis) Postoperative Complications Surgery, Plastic Time Factors

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