1-(1,3-Benzodioxol-5-yl-carbo-nyl) piperidine, a modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice.

Abstract

The current study was designed to investigate the effects of 1-(1,3-benzodioxol-5-yl-carbonyl) piperidine (1-BCP) on swimming endurance capacity which as one indicator of fatigue in the weight-loaded forced swimming mice. Mice were given either vehicle or 1-BCP (0.1, or 0.2 mmol/kg body weight daily) by intraperitoneal injection once daily for 2 weeks. The 1-BCP groups showed a significant increase in swimming time to exhaustion compared with the control group. 1-BCP increased the liver glycogen (LG) and muscle glycogen (MG) contents significantly, while decreased the lactic acid (LA) and blood urea nitrogen (BUN) levels notably compared with control group. Besides, 1-BCP treatment also significantly improved the endogenous cellular antioxidant enzymes in mice by increasing the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Therefore, this study demonstrated for the first time that the supplementation of 1-BCP, as a positive allosteric modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor, could enhance the endurance capacity of mice and facilitated them recovery from fatigue. Thus, we provide a new effective therapeutic strategy for fatigue.

• Authors: Wutu Fan, Xianglong Wu, Yalei Pan, Chenrui Li, Yinbo Niu, Yuankun Zhai, Qibing Mei
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 37 Issue 1 Pg. 13-7 ( 2014) ISSN: 1347-5215 [Electronic] Japan
• PMID: 24141261 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Dioxoles
• Piperidines
• Receptors, AMPA
• Lactic Acid
• 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine
• alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
• Glycogen
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase

Topics

• Animals
• Antioxidants (metabolism, pharmacology, therapeutic use)
• Blood Urea Nitrogen
• Catalase (metabolism)
• Dietary Supplements
• Dioxoles (pharmacology, therapeutic use)
• Fatigue (drug therapy, metabolism)
• Glutathione Peroxidase (metabolism)
• Glycogen (metabolism)
• Lactic Acid (blood)
• Liver (metabolism)
• Male
• Mice
• Mice, Inbred Strains
• Muscle, Skeletal (metabolism)
• Physical Endurance
• Piperidines (pharmacology, therapeutic use)
• Receptors, AMPA (metabolism)
• Superoxide Dismutase (metabolism)
• Swimming
• alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (metabolism)