BAG3 is upregulated by c-Jun and stabilizes JunD.

Abstract

BAG3 plays a regulatory role in a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, epithelial-mesenchymal transition (EMT), autophagy activation, and virus infection. The AP-1 transcription factors are implicated in a variety of important biological processes including cell differentiation, proliferation, apoptosis and oncogenesis. Recently, it has been reported that AP-1 protein c-Jun inhibits autophagy and enhances apoptotic cell death mediated by starvation. However, the molecular mechanisms remain unclear. For the first time, the current study demonstrated that serum starvation downregulated BAG3 at the transcriptional level via c-Jun. In addition, the current study reported that BAG3 stabilized JunD mRNA, which was, at least in part, responsible for the promotion of serum starvation mediated-growth inhibition by BAG3.

• Authors: Chao Li, Si Li, De-Hui Kong, Xin Meng, Zhi-Hong Zong, Bao-Qin Liu, Yifu Guan, Zhen-Xian Du, Hua-Qin Wang
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1833 Issue 12 Pg. 3346-3354 (Dec 2013) ISSN: 0006-3002 [Print] Netherlands
• PMID: 24140207 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013.

Chemical References

• Adaptor Proteins, Signal Transducing
• Apoptosis Regulatory Proteins
• BAG3 protein, human
• Culture Media, Serum-Free
• JunD protein, human
• Proto-Oncogene Proteins c-jun
• RNA, Messenger

Topics

• Adaptor Proteins, Signal Transducing (genetics, metabolism)
• Apoptosis Regulatory Proteins
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Culture Media, Serum-Free (pharmacology)
• Down-Regulation (drug effects, genetics)
• Humans
• Protein Stability (drug effects)
• Proto-Oncogene Proteins c-jun (metabolism)
• RNA Stability (drug effects)
• RNA, Messenger (genetics, metabolism)
• Transcription, Genetic (drug effects)
• Up-Regulation (drug effects, genetics)