Longitudinal evaluation using FP-CIT in patients with parkinsonism.

Abstract

OBJECTIVE:

To assess a group of patients with parkinsonism using serial studies with FP-CIT, basically the initial false negative results.

METHODS:

Restrospective study of 92 patients (55 men and 37 women) who had undergone 2 different FP-CIT studies because of discrepancies between study results and clinical progression. The mean elapsed time between the studies was 26 months (SD: 6). We performed a semi-quantitative study using the patient's clinical history and the available literature to analyse discrepant cases with a normal initial study and subsequent pathological findings.

RESULTS:

A total of 184 studies were completed for 92 patients; 11 of those 92 showed discrepancies between initial and subsequent studies. Among the 11 discrepant cases, 7 showed a normal initial study and pathological findings at a later date. Analysis of the predominant clinical features that might explain this behaviour revealed that 4 of these 7 subjects presented tremor-dominant parkinsonism. Regarding the rest, 1 presented early stage parkinsonism and was treated with antidopaminergic agents; 1 was classified as probable multisystem atrophy type C, and the third showed clinical signs of atypical parkinsonism without any causes of those signs being identified.

CONCLUSIONS:

Serial FP-CIT studies are unnecessary in the large majority of cases, but they may be justifiable in certain clinical situations.

• Authors: M D Martínez-Valle Torres, S J Ortega Lozano, M J Gómez Heredia, T Amrani Raissouni, E Ramos Moreno, P Moya Espinosa, J M Jiménez-Hoyuela
• Journal: Neurologia (Barcelona, Spain) (Neurologia) 2014 Jul-Aug Vol. 29 Issue 6 Pg. 327-33 ISSN: 1578-1968 [Electronic] Spain
• PMID: 24139386 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Chemical References

• Radiopharmaceuticals
• Tropanes
• 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

Topics

• Adult
• Aged
• Aged, 80 and over
• Case-Control Studies
• Diagnosis, Differential
• Essential Tremor (diagnosis)
• Female
• Humans
• Male
• Middle Aged
• Parkinsonian Disorders (diagnosis)
• Radiopharmaceuticals
• Tomography, Emission-Computed, Single-Photon (methods)
• Tropanes