Abstract |
The incidence of intrahepatic cholangiocarcinoma is increasing worldwide. The prognosis of intrahepatic cholangiocarcinoma is poor, and a better understanding of intrahepatic cholangiocarcinoma tumor biology is needed to more accurately predict clinical outcome and to suggest potential targets for more effective therapies. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and BRAF are frequently mutated oncogenes that promote carcinogenesis in a variety of tumor types. In this study, we analyze a large set of intrahepatic cholangiocarcinoma tumors (n = 54) for mutations in these genes and compare the clinical outcomes of wild type versus KRAS and BRAF mutant cases. Of 54 cases, 7.4% were mutant for KRAS, 7.4% were mutant for BRAF, and these were mutually exclusive. These mutant cases were associated with a higher tumor stage at time of resection and a greater likelihood of lymph node involvement. These cases were also associated with a worse long-term overall survival. Therefore, testing for KRAS and BRAF mutations could be a valuable adjunct in improving both prognosis and outcome stratification among patients with intrahepatic cholangiocarcinoma.
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Authors | Scott Robertson, Omar Hyder, Rebecca Dodson, Suresh K Nayar, Justin Poling, Katie Beierl, James R Eshleman, Ming-Tseh Lin, Timothy M Pawlik, Robert A Anders |
Journal | Human pathology
(Hum Pathol)
Vol. 44
Issue 12
Pg. 2768-73
(Dec 2013)
ISSN: 1532-8392 [Electronic] United States |
PMID | 24139215
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2013. |
Chemical References |
- KRAS protein, human
- Proto-Oncogene Proteins
- BRAF protein, human
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins p21(ras)
- ras Proteins
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Topics |
- Aged
- Cholangiocarcinoma
(genetics, mortality, pathology)
- Female
- Humans
- Liver Neoplasms
(genetics, mortality, pathology)
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Prognosis
- Proto-Oncogene Proteins
(genetics)
- Proto-Oncogene Proteins B-raf
(genetics)
- Proto-Oncogene Proteins p21(ras)
- Survival Rate
- ras Proteins
(genetics)
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