Antibody to glycolipid in a patient with IgM paraproteinemia and polyradiculoneuropathy.

Abstract

Serum from a patient with IgM paraproteinemia and polyradiculoneuropathy, diagnosed as malignant lymphoma reacted specifically with a lipid component in a crude ganglioside fraction isolated from human peripheral nerve, but did not react with myelin proteins including myelin-associated glycoprotein (MAG). The reactive glycolipid migrated between GM1 and GD1a gangliosides on TLC, and there was no distinct band corresponding to this glycolipid on examination with resorcinol reagent. Antibody to glycolipid in this case may play a role in the pathogenesis of neuropathy.

• Authors: H Baba, N Miyatani, S Sato, T Yuasa, T Miyatake
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 72 Issue 2 Pg. 218-21 (Aug 1985) ISSN: 0001-6314 [Print] Denmark
• PMID: 2413705 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Glycolipids
• Immunoglobulin M
• Myelin Proteins
• Myelin-Associated Glycoprotein

Topics

• Aged
• Autoantibodies (analysis)
• Glycolipids (immunology)
• Humans
• Immunoglobulin M
• Lymphoma (complications, immunology)
• Male
• Myelin Proteins (immunology)
• Myelin-Associated Glycoprotein
• Paraproteinemias (complications, immunology)
• Peripheral Nervous System Diseases (complications, immunology)