Targeted topical and combination laser surgery for the treatment of angiofibromas.

Abstract

BACKGROUND AND OBJECTIVE:

The angiofibromas of Tuberous sclerosis (TS) is well described manifestation. Due to the progressive nature of the skin lesion, a safe and effective technique for treating these disfiguring skin lesions is needed.

STUDY DESIGN/PATIENTS AND METHODS:

We report a targeted topical and combination laser technique for treating the angiofibromas of TS in one patient. This includes treatment with topical sirolimus, pinpoint electrosurgery, pulsed-dye laser treatment, and ablative fractional resurfacing (AFR).

RESULTS:

Improvement in the number and appearance of facial angiofibromas and erythema is noted, without scarring or adverse events.

CONCLUSION:

The technique of targeted therapy with sirolimus with electrosurgery, pulsed dye laser treatment, and AFR represents an innovative, safe therapeutic option for treating facial angiofibromas associated with TS.

• Authors: Yoon-Soo Cindy Bae-Harboe, Roy G Geronemus
• Journal: Lasers in surgery and medicine (Lasers Surg Med) Vol. 45 Issue 9 Pg. 555-7 (Nov 2013) ISSN: 1096-9101 [Electronic] United States
• PMID: 24136238 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 Wiley Periodicals, Inc.

Chemical References

• Antibiotics, Antineoplastic
• Sirolimus

Topics

• Adult
• Angiofibroma (drug therapy, etiology, surgery, therapy)
• Antibiotics, Antineoplastic (therapeutic use)
• Combined Modality Therapy
• Electrosurgery (methods)
• Facial Neoplasms (drug therapy, etiology, surgery, therapy)
• Female
• Humans
• Lasers, Dye (therapeutic use)
• Sirolimus (therapeutic use)
• Tuberous Sclerosis (complications)