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Overexpression of steroid receptor coactivator-3 in bone cancers: an in vivo immunohistochemical study with tissue microarray.

Abstract
Bone tissue is steroid-responsive and profoundly regulated by steroids and/or their receptors. Bone cancers (either primary or metastatic) belong to the most dangerous tumors. Previous studies have demonstrated overexpression of steroid receptor coactivator-3 (SRC-3) in many cancers, such as breast cancer, prostate cancer, thyroid cancer, functioning in the regulation of cancer cell proliferation, invasion, and metastasis. However, so far, the expression and function of SRC-3 in bone cancers have not yet been clarified. In this study, nickel-intensified immunohistochemistry was conducted using a commercial tissue microarray (with 94 cases of bone cancer tissue and 10 normal bone tissues), and the 4-scoring system was employed to evaluate the expression levels of SRC-3 immunoreactivity. The results showed that in normal bone tissue, levels of SRC-3 are almost negative (score=0), the total positivity (score=1-3) of SRC-3 immunoreactivities in bone cancers was 74.47%. There were no significant differences in gender, status (malignant or benign) or (mean) age (p>0.05). The percentage of positivity was 77.78% in osteogenic tumors, 58.82% in cartilage tumors, 70% in giant cell tumors, 100% in hematopoietic tumors, 77.78% in miscellaneous lesions, and 75% in miscellaneous tumors. Age related differences of SRC-3 immunoreactivities were detected in cartilage tumors and giant cell tumors (p<0.05). The above results clearly demonstrated a high frequency of overexpression of SRC-3 immunoreactivities in different bone cancers, indicating its potential roles in the prognosis and treatment of these cancers.
AuthorsFei Luo, Wei Li, Jiqiang Zhang, Ke Huang, Jingshu Fu, Zhao Xie
JournalPathology, research and practice (Pathol Res Pract) Vol. 209 Issue 12 Pg. 790-6 (Dec 2013) ISSN: 1618-0631 [Electronic] Germany
PMID24134957 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier GmbH. All rights reserved.
Chemical References
  • Biomarkers, Tumor
  • Nuclear Receptor Coactivator 3
Topics
  • Adult
  • Biomarkers, Tumor (metabolism)
  • Bone Neoplasms (diagnosis, metabolism)
  • Cell Proliferation
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Nuclear Receptor Coactivator 3 (metabolism)
  • Prognosis
  • Tissue Array Analysis

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