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Asthma and hemoglobinopathy: when is supplemental oxygen required?

Abstract
Asthma is the most common reason for referral to the emergency department in childhood. In severe attacks, supplemental O2 is given when oxygen saturation level is <90%. Described herein is the case of a child with persistent low oxygen saturation as measured on pulse oximetry (S(p)O2) after full clinical recovery from an asthma attack. Simultaneously, P(a)O2 was normal. A diagnosis of abnormal hemoglobin with decreased oxygen affinity (hemoglobin Seattle) was made on hemoglobin electrophoresis and genetic analysis. To ascertain when supplemental oxygen was needed, an oxygen dissociation curve was plotted using the tonometer technique, and it was found that an S(p)O2 of 70% is parallel to a P(a)O2 of 60 mmHg. Plotting an oxygen dissociation curve is a simple reproducible method to determine when supplemental oxygen is required for a child with a hemoglobinopathy.
AuthorsLeon Joseph, Inbal Brickner-Braun, Berry Pinshow, Shmuel Goldberg, Hagit Miskin, Elie Picard
JournalPediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 55 Issue 5 Pg. e133-5 (Oct 2013) ISSN: 1442-200X [Electronic] Australia
PMID24134768 (Publication Type: Case Reports, Journal Article)
Copyright© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.
Chemical References
  • Hemoglobins, Abnormal
  • hemoglobin Seattle
  • Oxygen
Topics
  • Asthma (blood, complications, therapy)
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Hemoglobinopathies (blood, etiology, therapy)
  • Hemoglobins, Abnormal (metabolism)
  • Humans
  • Oximetry
  • Oxygen (administration & dosage)
  • Oxygen Inhalation Therapy (methods)

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