Enhanced anti-obesity activities of red mold dioscorea when fermented using deep ocean water as the culture water.
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| Abstract |
Deep ocean water (DOW) has, in previous studies, been found to be a novel anti-obesity drink and useful in raising Monascus-produced monascin and ankaflavin levels. This may resolve the limited anti-obesity ability of red mold dioscorea (RMD) known as the Monascus purpureus-fermented Disocorea batatas. This study aims to compare the anti-obesity effect of DOW-cultured RMD (DOW-RMD) and ultra-pure water-cultured RMD (UPW-RMD) in rats fed on a high fat diet. Moreover, the effect of ions composition of DOW and DOW-influenced functional metabolites change of RMD on the differentiation and lipogenesis regulation were investigated using 3T3-L1 pre-adipocytes. In the animal test, compared to UPW-RMD, DOW-RMD possessed better ability to inhibit increases in weight gain, and better feed efficiency, body-fat pad and cross-sectional area of adipocytes. In the cell test, the anti-obesity abilities of DOW-RMD in inhibiting PPARγ and C/EBPα expression in differentiation and lipoprotein lipase activity in lipogenesis were contributed to by the DOW-increased monascin and ankaflavin levels and the ions of DOW, respectively.
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| Authors | Li-Chun Wang, Tzu-Ying Lung, Yi-Hsin Kung, Jyh-Jye Wang, Tsung-Yu Tsai, Bai-Luh Wei, Tzu-Ming Pan, Chun-Lin Lee |
| Journal | Marine drugs (Mar Drugs) Vol. 11 Issue 10 Pg. 3902-25 (Oct 15 2013) ISSN: 1660-3397 [Electronic] Switzerland |
| PMID | 24132179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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