Tonic pain response during inflammation and stress-induced corticosterone variations in prenatally stressed infant rats: effects of maternal buspirone injected during pregnancy.

Abstract

We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring. During the period of the hypothalamic-pituitary-adrenal system hyporeactivity, the pain response in the formalin test was associated with stress-related corticosterone variations. Maternal buspirone normalized the pain reaction in prenatally stressed rats during all periods of the formalin test and modified the dynamics of the corticosterone response. In 1 day after the formalin test, the basal level of this hormone in blood plasma remained increased. Maternal buspirone increased the resistance of the nociceptive and stress-systems to inflammatory-induced pain response in prenatally stressed rats.

• Authors: I P Butkevich, V A Mikhailenko, G V Makukhina, T R Bagaeva, Yu A Stolyarova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 155 Issue 2 Pg. 194-6 (Jun 2013) ISSN: 1573-8221 [Electronic] United States
• PMID: 24130987 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Serotonin 5-HT1 Receptor Agonists
• Buspirone
• Corticosterone

Topics

• Animals
• Behavior, Animal (drug effects)
• Buspirone (pharmacology)
• Corticosterone (blood)
• Female
• Inflammation (metabolism)
• Nociceptors (drug effects, metabolism)
• Pain (drug therapy)
• Pain Measurement
• Pregnancy
• Prenatal Exposure Delayed Effects
• Rats
• Serotonin 5-HT1 Receptor Agonists (pharmacology)
• Stress, Psychological