Effect of prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on the course of experimental depressive syndrome in rats.

Abstract

The effects of noncompetitive prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine were studied in rats with the experimental dopamine deficiency-dependent depressive syndrome induced by systemic injections of a pre-neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin for 14 days. The inhibitor (3.0 mg/kg, i.p., 30 min before pre-neurotoxin injection on days 8-14) alleviated depression symptoms and promoted normalization of behavioral activity after drug withdrawal. The obtained data reflected therapeutic antidepressant properties of inhibitor for prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine.

• Authors: N N Khlebnikova, N A Krupina, N G Bogdanova, I N Orlova, N N Zolotov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 155 Issue 2 Pg. 190-3 (Jun 2013) ISSN: 1573-8221 [Electronic] United States
• PMID: 24130986 (Publication Type: Journal Article)

Chemical References

• Pyrrolidines
• benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine
• methionyl-2-cyanopyrrolidine
• Sucrose
• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
• Methionine
• Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
• Serine Endopeptidases
• Prolyl Oligopeptidases
• Dopamine

Topics

• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (administration & dosage)
• Animals
• Anxiety (metabolism)
• Behavior, Animal (drug effects)
• Body Weight
• Depressive Disorder (drug therapy)
• Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (antagonists & inhibitors, blood, metabolism)
• Dopamine (deficiency)
• Male
• Methionine (analogs & derivatives, pharmacology, therapeutic use)
• Prolyl Oligopeptidases
• Pyrrolidines (pharmacology, therapeutic use)
• Rats
• Rats, Wistar
• Serine Endopeptidases (drug effects, metabolism)
• Sucrose (metabolism)