Cardioprotective effect of ethanolic extract of Urtica parviflora Roxb. against isoproterenol induced myocardial infarction in rats.

Abstract

OBJECTIVE:

The objective of this study is to evaluate the effect of ethanolic extract of Urtica parviflora Roxb. in isoproterenol (ISO) induced myocardial infarction (MI) in rats.

MATERIALS AND METHODS:

U. parviflora Roxb. (350 mg/kg and 500 mg/kg, p.o) was administered for 15 days in rats. MI was induced with a single dose of ISO (200 mg/kg, s.c.) on the 14(th) and 15(th) day. At the end of the experimental period (i.e., on the day 16), serum and heart tissues were collected and total cholesterol (TC), high density lipoprotein, triglyceride and malondialdehyde, superoxide dismutase, catalase (CAT), reduced glutathione (GSH) and body weight were determined.

RESULTS:

Administration of ISO in control rats showed a significant (P < 0.001) increase serum cholesterol alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and low density lipoprotein (LDL). There was a significant increase (P < 0.01) in the levels of heart tissues as compared with respective control groups. Rats treated with U. parviflora significantly (P < 0.01) decreased ALT, AST, ALP, LDL and TC. Moreover, there was an increased CAT and GSH levels in rat treated with U. parviflora Roxb. as compared with the control group.

CONCLUSION:

U. parviflora (350 and 500 mg/kg p.o.) is effective in controlling serum LDL levels and reduced cardiac complication in experimentally induced MI in rats.

• Authors: Nishith Ranjan Barman, Subhangkar Nandy, Rana Datta, Prasanna Kumar Kar
• Journal: Indian journal of pharmacology (Indian J Pharmacol) 2013 Sep-Oct Vol. 45 Issue 5 Pg. 513-6 ISSN: 1998-3751 [Electronic] India
• PMID: 24130389 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Plant Extracts
• Ethanol
• Aspartate Aminotransferases
• Alanine Transaminase
• Isoproterenol

Topics

• Adrenergic beta-Agonists (toxicity)
• Alanine Transaminase (metabolism)
• Animals
• Aspartate Aminotransferases (metabolism)
• Ethanol (chemistry)
• Female
• Isoproterenol (toxicity)
• Male
• Myocardial Infarction (chemically induced, prevention & control)
• Plant Extracts (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Urticaceae (chemistry)