Cyclophosphamide-induced cardiotoxicity with a prolonged clinical course diagnosed on an endomyocardial biopsy.

A 31-year-old woman with primary mediastinal large B-cell lymphoma refractory to conventional chemotherapy was treated with high-dose chemotherapy containing cyclophosphamide (CY). Subsequently, she was treated with auto peripheral blood stem cell transplantation. Although a complete remission was obtained, heart failure developed two months later. Echocardiography showed an impaired systolic function with pericardial effusion. A biopsy of the endomyocardial region from the left ventricle demonstrated spotty myocardial hemorrhage and myocardial fibrosis with disruption and aggregation of mitochondrial cristae. Based on these findings, CY-induced cardiotoxicity was diagnosed. The patient was treated with conventional therapy for heart failure, which required approximately one year to improve her condition.
AuthorsSaburo Kusumoto, Hiroaki Kawano, Tomayoshi Hayashi, Osami Satoh, Tsuyoshi Yonekura, Masamichi Eguchi, Masayoshi Takeno, Akira Tsuneto, Yuji Koide, Tatsuro Jo, Koji Maemura
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 52 Issue 20 Pg. 2311-5 ( 2013) ISSN: 1349-7235 [Electronic] Japan
PMID24126391 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents, Alkylating
  • Cardiotoxins
  • Cyclophosphamide
  • Adult
  • Antineoplastic Agents, Alkylating (adverse effects)
  • Biopsy
  • Cardiotoxins (adverse effects)
  • Cyclophosphamide (adverse effects)
  • Female
  • Heart Failure (chemically induced, diagnosis)
  • Humans
  • Myocardium (pathology)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: