Abstract | OBJECTIVE: METHODS: A total of 230 SD rats were randomized into gel, NSC, NSC plus self-assembly IKVAV nanofiber gel transplantation, normal saline and sham-operation groups. Function repair was evaluated by bundle branch block (BBB) score, immunofluorescence and Western blot respectively at Day 1, 3, 5, 7, 14, 28, 56 and 92 post-operation. RESULTS: CONCLUSION:
Transplantation with IKVAV nanofiber gel, NSC and NSC plus self-assembly IKVAV nanofiber gel may promote the repair of SCI in rats. But the method of NSC plus self-assembly IKVAV nanofiber gel is more effective.
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Authors | Rui Han, Lai-yong Tu, Ming-kun Yang, Tao Xu, Yan Ma, Xiao-juan Bi, Wei-bin Sheng |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 93
Issue 21
Pg. 1669-73
(Jun 04 2013)
ISSN: 0376-2491 [Print] China |
PMID | 24125680
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gels
- Laminin
- Peptide Fragments
- isoleucyl-lysyl-valyl-alanyl-valine
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Topics |
- Animals
- Gels
(therapeutic use)
- Laminin
(therapeutic use)
- Male
- Nanofibers
- Neural Stem Cells
(transplantation)
- Peptide Fragments
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Recovery of Function
- Spinal Cord Injuries
(surgery)
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