Neuropeptide K: a major tachykinin in plasma and tumor tissues from carcinoid patients.

Abstract

Evidence is presented for the presence of an entire family of tachykinin-immunoreactive peptides in plasma and tumor tissues from patients with carcinoid tumors. The peptides include in addition to substance P and neurokinin A; neurokinin B, an eledoisin like peptide and neuropeptide K--a 36 amino acid long tachykinin which contains neurokinin A at its C-terminus. Neuropeptide K seems to be the tachykinin which is present in highest concentrations in plasma as well as in acetic acid extracts of tumor tissues. It is highly biologically active, and may therefore contribute to the clinical symptoms of carcinoid tumors.

• Authors: E Theodorsson-Norheim, I Norheim, K Oberg, E Brodin, J M Lundberg, K Tatemoto, P G Lindgren
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 131 Issue 1 Pg. 77-83 (Aug 30 1985) ISSN: 0006-291X [Print] United States
• PMID: 2412557 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nerve Tissue Proteins
• Oligopeptides
• Tachykinins
• neuropeptide K
• Substance P
• Eledoisin
• Neurokinin A
• Neurokinin B

Topics

• Carcinoid Tumor (blood, metabolism)
• Chromatography, High Pressure Liquid
• Chromatography, Ion Exchange
• Eledoisin (metabolism)
• Humans
• Immunoassay
• Nerve Tissue Proteins (blood, metabolism)
• Neurokinin A
• Neurokinin B
• Oligopeptides (metabolism)
• Substance P (metabolism)
• Tachykinins