Abstract | BACKGROUND: MATERIAL AND METHODS: We subjected male Wistar rats to hemorrhagic shock by dropping the mean arterial blood pressure to 25-30 mm Hg for 60 min, resuscitated with acetated Ringer's ( AR) solution, LR solution, RS, or normal saline (NS) within 30 min, and further observed the animals for 180 min. RESULTS: CONCLUSIONS: In severe hemorrhagic shock, resuscitation with both RS and NS is superior to administration of LR solution but initial outcome is even further improved if AR solution is used. Mere amelioration of the acid-base status by AR solution may explain its superior role compared with RS and NS but cannot be responsible for its superiority compared with LR solution. Here, direct injury by lactate has to be discussed.
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Authors | Ricarda Rohrig, Christoph Wegewitz, Sven Lendemans, Frank Petrat, Herbert de Groot |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 186
Issue 1
Pg. 338-45
(Jan 2014)
ISSN: 1095-8673 [Electronic] United States |
PMID | 24124975
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2014. Published by Elsevier Inc. |
Chemical References |
- AR solution
- Acetates
- Electrolytes
- Isotonic Solutions
- Ringer's Lactate
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Topics |
- Acetates
- Animals
- Disease Models, Animal
- Electrolytes
(blood)
- Hematocrit
- Hemodynamics
- Isotonic Solutions
(therapeutic use)
- Male
- Rats
- Rats, Wistar
- Ringer's Lactate
- Shock, Hemorrhagic
(drug therapy, mortality, physiopathology)
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