Association between tumor necrosis factor-α 308G/A gene polymorphism and silicosis susceptibility: a meta-analysis.

Abstract

BACKGROUND:

Tumor necrosis factor-α (TNF-α) 308 G/A gene polymorphism has been reported to be associated with susceptibility to silicosis. However, the relevant study results are still inconsistent.

OBJECTIVE AND METHODS:

A meta-analysis was performed in order to drive a more precise estimation of the relationship between TNF-α-308 G/A gene polymorphism and susceptibility to silicosis. Electronic databases were searched and nine separate studies were included. The pooled odds ratios (ORs) and the corresponding 95% confidence internal (CI) were calculated by a fixed effect model.

RESULTS:

A total of 1267 cases and 1214 controls were included. In the overall analysis, significantly increased silicosis risk was found (for GA+AA vs. GG OR=1.45, 95%CI: 1.20-1.760, P=1.58E4; for GA vs. GG: OR=1.53, 95%CI=1.25-1.86, P=3.11E5; for A allele vs. G allele: OR=1.27, 95%CI=1.08-1.50, P= 0.004). In the subgroup analysis, significantly increased silicosis risk was also found among Asians (for GA+AA vs. GG: OR=1.63, 95%CI=1.27-2.08, P=1.01E4), for GA vs. GG: OR=1.71, 95%CI=1.33-2.20, P=3.44E5), for A allele vs. G allele: OR=1.45, 95%CI=1.17-1.80, P=0.001). However, no significantly increased risk was found among non-Asians for all genetic models.

CONCLUSIONS:

TNF-α-308 G/A polymorphism might lead to an increased risk of silicosis susceptibility, especially for Asians. However, further studies with large sample sizes should be conducted to confirm the association.

• Authors: Zhanzhan Li, Jing Xue, Shipeng Yan, Peng Chen, Lizhang Chen
• Journal: PloS one (PLoS One) Vol. 8 Issue 10 Pg. e76614 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 24124578 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Codon
• Tumor Necrosis Factor-alpha

Topics

• Alleles
• Codon
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Odds Ratio
• Polymorphism, Single Nucleotide
• Publication Bias
• Silicosis (genetics)
• Tumor Necrosis Factor-alpha (genetics)