Thermoresponsive dendrimers based on oligoethylene glycols: design, synthesis and cytotoxic activity against MCF-7 breast cancer cells.

Abstract

Three interesting thermoresponsive branched oligoethylene glycol dendrimers based on tetrabromohydroquinone were efficiently synthesized from tetrabromohydroquinone and three different oligoethylene glycol derivatives. By visual inspection, all these dendrimers are water-soluble at room temperature. The thermoresponsive behaviors were investigated by using UV/vis turbidity measurement at different temperatures for 0.25 wt% of aqueous solutions from D1, D2 and D3. The cytotoxicity of the prepared dendrimers was tested against MCF-7 breast cancer cells. All tested dendrimers showed considerable results, where D2 dendrimer gave the best result; it showed cytotoxicity against MCF-7 cell line with IC₅₀ of 1.07 μg/mL and resistant fraction equals 1.97%, the other two dendrimers showed a modest cytotoxic profile.

• Authors: Mona A Abdel-Rahman, Ahmed M Al-Abd
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 69 Pg. 848-54 (Nov 2013) ISSN: 1768-3254 [Electronic] France
• PMID: 24121308 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Chemical References

• 2,3,5,6-tetrabromohydroquinone
• Antineoplastic Agents
• Dendrimers
• Hydroquinones
• Polyethylene Glycols

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology, toxicity)
• Cell Proliferation (drug effects)
• Dendrimers (chemical synthesis, chemistry, pharmacology, toxicity)
• Dose-Response Relationship, Drug
• Drug Design
• Humans
• Hydroquinones (chemistry)
• MCF-7 Cells
• Polyethylene Glycols (chemical synthesis, chemistry, pharmacology, toxicity)
• Structure-Activity Relationship
• Temperature