HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Synthesis, X-ray structure, interactions with DNA, remarkable in vivo tumor growth suppression and nephroprotective activity of cis-tetrachloro-dipivalato dirhenium(III).

Abstract
In this study we report the synthesis, the X-ray crystal structure and the in vivo tumor growth suppression and nephroprotective activity of bis-dimethylsulfoxide-cis-tetrachlorodi-μ-pivalatodirhenium(III), cis-Re2[(CH3)3CCOO]2Cl4·2(CH3)2SO (I). The interactions of I with DNA were also investigated by electrophoretic mobility shift assays, electronic absorption titrations, ΔTm and viscosity measurements, which indicate that compound I interacts relatively strongly with the DNA (Kb 2.2×10(3)M(-1)), most likely by forming covalent interstrand cross-links, and by kinking and unwinding supercoiled DNA; moreover, DNA cleavage by I is enhanced in the presence of redox-active species. The in vivo antitumor activity of I is considerable and is accompanied by significant elimination of red blood cell and kidney damage. Remarkably, compound I in combination with cisplatin (combined Re-Pt antitumor system) led to suppression of tumor growth or complete tumor elimination. The antihemolytic and nephroprotective abilities of I only or as a part of the Re-Pt antitumor system were established and a possible mechanism for the influence of I on these properties, involving erythropoietin production, is proposed.
AuthorsNatalia I Shtemenko, Helen T Chifotides, Konstantin V Domasevitch, Alexander A Golichenko, Svetlana A Babiy, Zhanyong Li, Katherina V Paramonova, Alexander V Shtemenko, Kim R Dunbar
JournalJournal of inorganic biochemistry (J Inorg Biochem) Vol. 129 Pg. 127-34 (Dec 2013) ISSN: 1873-3344 [Electronic] United States
PMID24121302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013.
Chemical References
  • Antineoplastic Agents
  • DNA, Neoplasm
  • Rhenium
  • Cisplatin
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Cisplatin (chemistry, pharmacology)
  • Crystallography, X-Ray
  • DNA, Neoplasm (chemistry, metabolism)
  • Drug Screening Assays, Antitumor
  • Neoplasms, Experimental (drug therapy, metabolism, pathology)
  • Oxidation-Reduction
  • Rats
  • Rats, Wistar
  • Rhenium (chemistry, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: