Abstract |
This study aimed at investigating the efficacy of Kalpaamruthaa (KA) on cardiovascular damage (CVD) associated with type 2 diabetes mellitus in experimental rats by reducing oxidative stress and the modulation of the protein kinase C-β (PKC-β)/Akt signaling pathway. CVD-induced rats were treated with KA (200 mg·(kg body mass)(-1)·(day)(-1)) orally for 4 weeks. KA effectively reduced insulin resistance with alterations in blood glucose, hemoglobin, and glycosylated hemoglobin in CVD-induced rats. Elevated levels of lipids in CVD-induced rats were decreased upon KA administration. In CVD-induced rats the levels of lipoproteins were returned to normal by KA treatment. KA effectively reduced the lipid peroxidative product and protein carbonyl content in liver of CVD-induced rats. KA increased the activities and (or) levels of enzymatic and nonenzymatic antioxidants in liver of CVD-induced rats. KA treatment reduced the fatty inclusion and mast cell infiltration in liver of CVD-induced rats. Further, treatment with KA reduced the chromatin condensation and marginization in myocardium of CVD-induced rats. KA alters insulin signaling by decreasing PKC-β and increasing p-Akt and GLUT4 expressions in heart of CVD-induced rats. The above findings suggest that KA renders protection against CVD induced by type 2 diabetes mellitus by augmenting the cellular antioxidant defense capacity and modulating PKC-β and the p-Akt signaling pathway.
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Authors | Raja Latha, Palanivelu Shanthi, Panchanadham Sachdanandam |
Journal | Canadian journal of physiology and pharmacology
(Can J Physiol Pharmacol)
Vol. 91
Issue 11
Pg. 901-12
(Nov 2013)
ISSN: 1205-7541 [Electronic] Canada |
PMID | 24117257
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glucose Transporter Type 4
- Kalpaamruthaa
- Lipids
- Lipoproteins
- Plant Extracts
- Slc2a4 protein, rat
- Proto-Oncogene Proteins c-akt
- Protein Kinase C beta
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Blotting, Western
- Diabetes Mellitus, Experimental
(metabolism)
- Diabetes Mellitus, Type 2
(complications)
- Diabetic Cardiomyopathies
(drug therapy, metabolism, pathology)
- Glucose Transporter Type 4
(metabolism)
- Immunohistochemistry
- Lipid Metabolism
(drug effects)
- Lipids
(blood)
- Lipoproteins
(blood)
- Male
- Mast Cells
(drug effects)
- Microscopy, Electron, Transmission
- Myocardium
(pathology)
- Oxidative Stress
(drug effects)
- Plant Extracts
(pharmacology)
- Protein Carbonylation
(drug effects)
- Protein Kinase C beta
(metabolism, physiology)
- Proto-Oncogene Proteins c-akt
(metabolism, physiology)
- Rats
- Rats, Sprague-Dawley
- Signal Transduction
(drug effects)
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