Abstract | BACKGROUND: METHODS: A total of 45 children composed of 15 children per group of malnutrition ( marasmus, marasmic- kwashiorkor, and kwashiorkor) were studied during malnutrition and after nutritional recovery. After an overnight fast, patients ingested 3 mg/kg 13C-caffeine at 0900 h. Duplicate breath samples were collected into an Exetainer bottle at -20, -10, and -1 min and at 15-min intervals for 2 h. The mean cumulative percent dose recovered (CPDR) of 13C-caffeine in the expired 13CO2 was determined over the study period. RESULTS: The CPDR in the expired 13CO2 in 2 h significantly increased after nutritional recovery in children with marasmus (from 6.80%±3.00% to 7.67%±2.81%; Student's t-test, p=0.001), marasmic- kwashiorkor (from 6.61%±2.26% to 7.56%±2.46%, p=0.041), and kwashiorkor (from 6.29%±1.06% to 7.20%±1.80%, p=0.002). When the three groups of malnutrition were compared, there was no significant difference in their mean CPDR in 2 h during malnutrition [p=0.820, analysis of variance (ANOVA)] and after nutritional recovery (p=0.810, ANOVA). CONCLUSIONS:
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Authors | Kazeem Adeola Oshikoya, Kenneth Smith, Helen Sammons, Imti Choonara |
Journal | Journal of basic and clinical physiology and pharmacology
(J Basic Clin Physiol Pharmacol)
Vol. 26
Issue 1
Pg. 105-13
(Jan 2015)
ISSN: 2191-0286 [Electronic] Germany |
PMID | 24114907
(Publication Type: Journal Article)
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Chemical References |
- Carbon Isotopes
- Caffeine
- Cytochrome P-450 CYP1A2
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Topics |
- Breath Tests
- Caffeine
(metabolism)
- Carbon Isotopes
- Child
- Child, Preschool
- Cytochrome P-450 CYP1A2
(metabolism)
- Female
- Humans
- Kwashiorkor
(physiopathology)
- Liver
(metabolism)
- Male
- Protein-Energy Malnutrition
(physiopathology)
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