Arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium.
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| Abstract |
Arctigenin, a lignan extract from Arctium lappa (L.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. However, the effects of arctigenin on bronchus relaxation are not well investigated. This study aimed to investigate how arctigenin regulates bronchus tone and calcium ion (Ca(2+)) flow. Trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, KCl, and CaCl2, respectively. Furthermore, L-type calcium channel currents were detected by patch-clamp, and intracellular Ca(2+) concentration was detected by confocal microscopy. The results showed that arctigenin exhibited relaxation effect on tracheae to different constrictors, and this was related to decreasing cytoplasmic Ca(2+) concentration by inhibiting Ca(2+) influx partly through L-type calcium channel as well as promoting Ca(2+) efflux. In summary, this study provides new insight into the mechanisms by which arctigenin exhibits relaxation effect on bronchus and suggests its potential use for airway disease therapy.
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| Authors | Zhenying Zhao, Yongqiang Yin, Zengyong Wang, Runping Fang, Hong Wu, Min Jiang, Gang Bai, Guo'an Luo |
| Journal | Biological trace element research (Biol Trace Elem Res) Vol. 156 Issue 1-3 Pg. 181-7 (Dec 2013) ISSN: 1559-0720 [Electronic] United States |
| PMID | 24114345 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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