[Therapeutic effect of Robaveron tablet (KN-7) on urinary disturbance by benign prostatic hypertrophy].

Abstract

Therapeutic effect of Robaveron tablet (KN-7) was studied on 101 patients with urinary disturbance accompanied by benign prostatic hypertrophy. Robaveron tablet, which contains 20 mg of a swine prostatic extract per tablet, was administered 6 tablets daily for 3 weeks in principle. Evaluation of drug efficacy was based on residual urine, cystometric findings, urethral pressure profile, uroflowmetry and subjective symptoms. Remarkable decrease of residual urine was observed at all stages of Guyon classification, in parallel with increases of cystometric pressure amplitude and average flow rate. Rate of residual urine reduction rose in proportion to the higher stage or bulkier volume of residual urine. Improvements of subjective symptoms were also obtained. The overall effectiveness, rated slightly improved or better was 76.8%. Side effects were seen at a low rate of 3.9%, and there were no abnormal changes directly due to the drug in clinical laboratory tests. These results indicate that Robaveron tablets act on the detrusor muscle and contribute to improve the depressed voiding efficiency and incidental symptoms of the subjects.

• Authors: T Sonoda, H Endo, A Maru, K Sasaki, K Kuroda, T Takamura, F Inada, M Rokuzyo, T Ohori, T Kubo
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 31 Issue 3 Pg. 553-62 (Mar 1985) ISSN: 0018-1994 [Print] Japan
• PMID: 2411118 (Publication Type: English Abstract, Journal Article)

Chemical References

• Robaveron
• Tablets
• Tissue Extracts

Topics

• Aged
• Drug Evaluation
• Humans
• Male
• Middle Aged
• Prostatic Hyperplasia (complications, drug therapy)
• Tablets
• Tissue Extracts (administration & dosage, adverse effects, therapeutic use)
• Urination Disorders (drug therapy, etiology)
• Urodynamics