Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population.

Abstract

BACKGROUND:

Single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be related with susceptibility to several human cancers. We evaluated the associations of rs3746444 in pre-miRNA hsa-mir-499 with the risk of gastric cancer (GC) in the Chinese population.

PATIENTS AND METHODS:

The rs3746444 (A>G) SNPs were genotyped in 201 GC and 213 non-cancer subjects in a case-control study by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

RESULTS:

There was no significant overall difference in the genotype distributions of rs3746444 (A>G) SNPs between cases and controls. In the logistic regression analyses, no significantly increased risk of GC was found to be associated with variant genotypes.

CONCLUSION:

The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population.

• Authors: Xiao-Jin Wu, Yan-Yan Mi, Hui Yang, An-Kang Hu, Chen Li, Xiao-Dong Li, Qing-Guo Zhang
• Journal: Onkologie (Onkologie) Vol. 36 Issue 10 Pg. 573-6 ( 2013) ISSN: 1423-0240 [Electronic] Switzerland
• PMID: 24107911 (Publication Type: Journal Article)
• Copyright: © 2013 S. Karger GmbH, Freiburg.

Chemical References

• Genetic Markers
• MIRN499 microRNA, human
• MicroRNAs

Topics

• Aged
• Aged, 80 and over
• China (epidemiology)
• Female
• Genetic Association Studies
• Genetic Markers (genetics)
• Genetic Predisposition to Disease (epidemiology, genetics)
• Humans
• Male
• MicroRNAs (genetics)
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Prevalence
• Risk Assessment
• Stomach Neoplasms (epidemiology, genetics)