Abstract |
The objectives of the present study were to determine the relative efficacy of tulathromycin, azithromycin, or azithromycin with rifampin for the treatment of pulmonary abscesses on a farm with endemic infections caused by Rhodococcus equi. Foals with ultrasonographic evidence of pulmonary abscesses ( abscess score 8.0-15 cm; n=120) were randomly allocated in four equal treatment groups: (1) tulathromycin intramuscularly; (2) azithromycin monotherapy, orally; (3) azithromycin with rifampin, orally; (4) saline intramuscularly as a placebo. Physical examination and thoracic ultrasonography were performed by individuals unaware of treatment group assignment. Foals that worsened were removed from the study. The proportion of foals that recovered without the need for a change in therapy was significantly higher for foals treated with azithromycin (29 of 30) or azithromycin with rifampin (28 of 30) than for foals treated with a placebo (20 of 30). Additionally, azithromycin or azithromycin with rifampin resulted in a significantly faster decrease in the number of abscesses and abscess score compared with a placebo. The proportion of foals treated with tulathromycin that recovered (27 of 30) was not significantly different from that of foals treated with a placebo. Azithromycin alone or in combination with rifampin was beneficial in the study population.
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Authors | M Venner, N Credner, M Lämmer, S Giguère |
Journal | The Veterinary record
(Vet Rec)
Vol. 173
Issue 16
Pg. 397
(Oct 26 2013)
ISSN: 2042-7670 [Electronic] England |
PMID | 24106244
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Disaccharides
- Heterocyclic Compounds
- Azithromycin
- tulathromycin
- Rifampin
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Topics |
- Actinomycetales Infections
(drug therapy, epidemiology, veterinary)
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Azithromycin
(therapeutic use)
- Disaccharides
(therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
(veterinary)
- Endemic Diseases
(veterinary)
- Germany
(epidemiology)
- Heterocyclic Compounds
(therapeutic use)
- Horse Diseases
(drug therapy, epidemiology)
- Horses
- Lung Abscess
(drug therapy, veterinary)
- Pneumonia, Bacterial
(drug therapy, microbiology, veterinary)
- Rhodococcus equi
- Rifampin
(therapeutic use)
- Severity of Illness Index
- Treatment Outcome
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