Association between serum cystatin C levels and coronary slow flow.

Abstract

We assessed the association between serum cystatin C (CysC) levels and coronary slow flow (CSF) phenomenon in patients who underwent coronary angiography. A total of 210 patients (mean age 55.6 ± 10.9 years; 100 females) were included. Patients were divided into 3 groups, (patients with CSF [group 2], with coronary artery disease [CAD; group 3], and without CAD [group 1]). Serum CysC levels in patients with CSF were significantly lower than those with and without CAD (912.5 ± 135.6, 820.4 ± 104.2, and 1343.4 ± 236.6 ng/mL in groups 1, 2, and 3, respectively; P < .001). Serum CysC levels correlated with the number of vessels with CSF and mean corrected thrombolysis in myocardial infarction frame count (Spearman correlation coefficient [r s] = .192, P < .001 and r s = .261, P < .001 respectively). In conclusion, patients with CSF have lower CysC levels; this could be a useful biomarker of CSF involvement in patients who undergo diagnostic coronary angiography.

• Authors: Abdurrahman Tasal, Ahmet Bacaksiz, Gokhan Ertas, Mehmet Akif Vatankulu, Seref Kul, Soner Sari, Muhammed Emin Dãœz, Ercan Erdogan, Osman Sonmez, Omer Goktekin
• Journal: Angiology (Angiology) Vol. 65 Issue 9 Pg. 831-7 (Oct 2014) ISSN: 1940-1574 [Electronic] United States
• PMID: 24101711 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2013.

Chemical References

• Biomarkers
• CST3 protein, human
• Cystatin C

Topics

• Aged
• Biomarkers (blood)
• Coronary Angiography
• Coronary Artery Disease (blood, diagnostic imaging, physiopathology)
• Coronary Circulation
• Cystatin C (blood)
• Down-Regulation
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Severity of Illness Index
• Time Factors