HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation.

AbstractPURPOSE OF REVIEW:
Tumor necrosis factor (TNF)-like cytokine 1A (TL1A) associates with the death receptor 3 (DR3) on activated lymphocytes and induces proinflammatory signals. The decoy receptor 3 (DcR3) competes for TL1A binding and inhibits functional signaling. This review focuses on the role of the TL1A/DR3/DcR3 cytokine system in inflammatory bowel diseases (IBDs).
RECENT FINDINGS:
TL1A may induce IFN-γ-mediated and IL-17-mediated proinflammatory pathways in IBDs by acting on DR3-expressing, CD4(+)CD161(+) lymphocytes, which are substantially enriched at the inflamed intestinal mucosa. In addition, TL1A/DR3 signaling results in expansion of the Treg pool with concomitant and transient inhibition of their suppressive function. Constitutive expression of TL1A in transgenic mice was associated with small intestinal inflammation, which was accompanied by colonic fibrosis both spontaneously and under colitogenic conditions. Recent human studies demonstrated that soluble TL1A and DcR3 are present in the systemic circulation in patients with active IBD and decline after successful anti-inflammatory treatment.
SUMMARY:
TL1A/DR3 interactions may participate in the pathogenesis of chronic intestinal inflammation and offer novel therapeutic targets for patients with ulcerative colitis and Crohn's disease.
AuthorsGiorgos Bamias, Li-Guo Jia, Fabio Cominelli
JournalCurrent opinion in gastroenterology (Curr Opin Gastroenterol) Vol. 29 Issue 6 Pg. 597-602 (Nov 2013) ISSN: 1531-7056 [Electronic] United States
PMID24100723 (Publication Type: Journal Article, Review)
Chemical References
  • Biomarkers
  • Cytokines
  • Inflammation Mediators
  • Receptors, Tumor Necrosis Factor, Member 25
  • Tumor Necrosis Factor Ligand Superfamily Member 15
Topics
  • Animals
  • Biomarkers (blood)
  • Cytokines (biosynthesis)
  • Fibrosis (immunology)
  • Humans
  • Inflammation Mediators (immunology)
  • Inflammatory Bowel Diseases (immunology)
  • Receptors, Tumor Necrosis Factor, Member 25 (immunology)
  • T-Lymphocytes, Regulatory (immunology)
  • Tumor Necrosis Factor Ligand Superfamily Member 15 (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: