Effects of high-fluoride dentifrice (5,000-ppm) on caries-related plaque and salivary variables.

Abstract

OBJECTIVES:

The aim of the present study was to measure the effects of a 5,000-ppm F toothpaste on caries-related factors in dental plaque and saliva.

MATERIALS AND METHODS:

A 6-week clinical trial was designed with a total of 34 participants, of which 26 completed the study. The participants were assessed on four visits, 2 weeks apart. Sampling of approximal fluid for fluoride analysis and approximal plaque for organic acid analysis was performed. Chair-side tests were performed to register the lactic acid production rate on the tongue using Clinpro™ Cario L-Pop™, approximal plaque pH using the pH "strip method" and salivary buffer capacity and counts of cariogenic microorganisms using CRT Buffer(®) and CRT Bacteria(®).

RESULTS:

Six weeks' use of 5,000-ppm fluoridated (F) toothpaste significantly increased the approximal fluid F concentration (p < 0.05). There was a significant decrease in lactic acid production rate on the tongue assessed by Clinpro™ (p < 0.05). This was accompanied by changes in interproximal plaque acidogenicity, including significant reductions in AUC(5.7), AUC(6.2) and maximum pH fall and an increase in minimum pH (p < 0.05). A significant increase in the salivary buffer capacity and a reduction in the salivary mutans streptococci were observed (p < 0.05).

CONCLUSION:

The present study demonstrates the ability of 5,000-ppm F toothpaste to modify caries-related factors in dental plaque and saliva.

CLINICAL RELEVANCE:

The 5,000-ppm F toothpaste could be regarded as a possible effective regimen against caries in the near future.

• Authors: Alaa Mannaa, Anette Carlén, Egija Zaura, Mark J Buijs, Sahar Bukhary, Peter Lingström
• Journal: Clinical oral investigations (Clin Oral Investig) Vol. 18 Issue 5 Pg. 1419-26 ( 2014) ISSN: 1436-3771 [Electronic] Germany
• PMID: 24100637 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dentifrices
• Fluorides

Topics

• Adolescent
• Dental Caries (physiopathology)
• Dental Plaque
• Dentifrices
• Fluorides (administration & dosage)
• Humans
• Saliva