HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of chronic activity-based therapy on bone mineral density and bone turnover in persons with spinal cord injury.

AbstractPURPOSE:
Osteoporosis is a severe complication of spinal cord injury (SCI). Many exercise modalities are used to slow bone loss, yet their efficacy is equivocal. This study examined the effect of activity-based therapy (ABT) targeting the lower extremities on bone health in individuals with SCI.
METHODS:
Thirteen men and women with SCI (age and injury duration = 29.7 ± 7.8 and 1.9 ± 2.7 years) underwent 6 months of ABT. At baseline and after 3 and 6 months of training, blood samples were obtained to assess bone formation (serum procollagen type 1 N propeptide (PINP) and bone resorption (serum C-terminal telopeptide of type I collagen (CTX), and participants underwent dual-energy X-ray absorptiometry scans to obtain total body and regional estimates of bone mineral density (BMD).
RESULTS:
Results demonstrated significant increases (p < 0.05) in spine BMD (+4.8 %; 1.27 ± 0.22-1.33 ± 0.24 g/cm(2)) and decreases (p < 0.01) in total hip BMD (-6.1 %; 0.98 ± 0.18-0.91 ± 0.16 g/cm(2)) from 0 to 6 months of training. BMD at the bilateral distal femur (-7.5 to -11.0 %) and proximal tibia (- 8.0 to -11.2 %) declined but was not different (p > 0.05) versus baseline. Neither PINP nor CTX was altered (p > 0.05) with training.
CONCLUSIONS:
Chronic activity-based therapy did not reverse bone loss typically observed soon after injury, yet reductions in BMD were less than the expected magnitude of decline in lower extremity BMD in persons with recent SCI.
AuthorsTodd Anthony Astorino, Eric T Harness, Kara A Witzke
JournalEuropean journal of applied physiology (Eur J Appl Physiol) Vol. 113 Issue 12 Pg. 3027-37 (Dec 2013) ISSN: 1439-6327 [Electronic] Germany
PMID24097172 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Collagen Type I
  • Peptide Fragments
  • Peptides
  • Procollagen
  • collagen type I trimeric cross-linked peptide
  • procollagen Type I N-terminal peptide
Topics
  • Adult
  • Bone Density
  • Bone and Bones (diagnostic imaging)
  • Collagen Type I (blood)
  • Exercise Therapy
  • Female
  • Humans
  • Male
  • Peptide Fragments (blood)
  • Peptides (blood)
  • Procollagen (blood)
  • Radiography
  • Spinal Cord Injuries (blood, physiopathology, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: