Abstract |
The nutrient-sensing lipolytic enzyme adipose triglyceride lipase (ATGL) has a key role in adipose tissue function, and alterations in its activity have been implicated in many age-related metabolic disorders. In adipose tissue reduced blood vessel density is related to hypoxia state, cell death and inflammation. Here we demonstrate that adipocytes of poorly vascularized enlarged visceral adipose tissue (i.e. adipose tissue of old mice) suffer from limited nutrient delivery. In particular, nutrient starvation elicits increased activity of mitochondrial proline oxidase/ dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL. We demonstrate that ATGL promotes the expression of genes related to mitochondrial oxidative metabolism ( peroxisome proliferator-activated receptor-α, peroxisome proliferator-activated receptor-γ coactivator-1α), thus setting a metabolic switch towards fat utilization that supplies energy to starved adipocytes and prevents cell death, as well as adipose tissue inflammation. Taken together, these results identify ATGL as a stress resistance mediator in adipocytes, restraining visceral adipose tissue dysfunction typical of age-related metabolic disorders.
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Authors | D Lettieri Barbato, K Aquilano, S Baldelli, S M Cannata, S Bernardini, G Rotilio, M R Ciriolo |
Journal | Cell death and differentiation
(Cell Death Differ)
Vol. 21
Issue 1
Pg. 113-23
(Jan 2014)
ISSN: 1476-5403 [Electronic] England |
PMID | 24096872
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Forkhead Box Protein O1
- Forkhead Transcription Factors
- Foxo1 protein, mouse
- PPAR alpha
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Ppargc1a protein, mouse
- RNA, Messenger
- RNA, Small Interfering
- Reactive Oxygen Species
- Transcription Factors
- Proline Oxidase
- Lipase
- PNPLA2 protein, mouse
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Topics |
- 3T3-L1 Cells
- Adipose Tissue
(metabolism)
- Animals
- Apoptosis
- Diet
- Forkhead Box Protein O1
- Forkhead Transcription Factors
(antagonists & inhibitors, genetics, metabolism)
- Inflammation
- Lipase
(genetics, metabolism)
- Mice
- Mitochondria
(metabolism)
- PPAR alpha
(metabolism)
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Proline Oxidase
(metabolism)
- RNA Interference
- RNA, Messenger
(metabolism)
- RNA, Small Interfering
(metabolism)
- Reactive Oxygen Species
(metabolism)
- Transcription Factors
(metabolism)
- Up-Regulation
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