Inhibition of Rous sarcoma virus production by formycin.

Abstract

The effect of formycin, an adenosine analog, on the growth of chick embryo fibroblasts and on Rous sarcoma virus (RSV) production was studied. An adverse effect on cell proliferation was observed in the presence of 10 microM formycin. Treatment with 5 microM formycin for 24 hr reduced by a factor of about 1000 the yield of infections progeny whereas the cell growth remained unaltered. Moreover the few particles released in the presence of formycin showed a markedly decreased ability to synthesize viral cDNA. This impairment was shown to be related to a nonfunctional primer tRNA.

• Authors: L Sarih, B Agoutin, O Lecoq, D Weill, P Jullien, T Heyman
• Journal: Virology (Virology) Vol. 145 Issue 1 Pg. 171-5 (Aug 1985) ISSN: 0042-6822 [Print] United States
• PMID: 2409669 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• DNA, Viral
• Formycins
• RNA primers
• RNA, Viral
• RNA
• formycin
• DNA
• RNA, Transfer

Topics

• Animals
• Antibiotics, Antineoplastic (pharmacology)
• Avian Sarcoma Viruses (drug effects, growth & development, metabolism)
• Cell Division (drug effects)
• Cell Transformation, Viral (drug effects)
• Cells, Cultured
• Chick Embryo
• DNA (biosynthesis)
• DNA, Viral (biosynthesis)
• Formycins (analysis, metabolism, pharmacology)
• RNA (analysis, metabolism)
• RNA, Transfer (analysis, metabolism)
• RNA, Viral (analysis, metabolism)