Quantitative volumetric analysis of progressive hemifacial atrophy corrected using stromal vascular fraction-supplemented autologous fat grafts.

Abstract

BACKGROUND:

Progressive hemifacial atrophy (Parry-Romberg disease) is rare and involves all skin layers and subcutaneous soft and hard tissue. Autologous fat grafting has revolutionized the field of soft-tissue reconstruction and augmentation, but long-term maintenance is unpredictable. Stromal vascular fraction (SVF)-supplemented cell therapy offers new hope for improving fat graft survival, with good long-term results, but efficacy and long-term outcome in the clinic are rarely studied using objective data.

OBJECTIVE:

To compare the long-term viability of SVF-supplemented fat grafts and fat grafts alone for contour reconstruction of progressive hemifacial atrophy using quantitative volume analysis.

METHODS:

We treated 20 patients with stable hemifacial atrophy for at least 2 years with SVF-supplemented autologous fat grafting (n = 10) or fat grafting alone (n = 10). All patients were followed up every 3 months. Hemifacial volume was measured using computed tomography and the Philips Extended Brilliance Workspace.

RESULTS:

All patients had successful outcomes without complications, but fat survival and clinical improvement was greater with SVF-supplemented grafting than fat grafting alone after 6 months.

CONCLUSION:

SVF-supplemented autologous fat transplantation is effective and safe for treating progressive hemifacial atrophy and can enhance the survival of grafts in the face without major complications.

• Authors: Qiang Chang, Jie Li, Ziqing Dong, Linqi Liu, Feng Lu
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 39 Issue 10 Pg. 1465-73 (Oct 2013) ISSN: 1524-4725 [Electronic] United States
• PMID: 24090256 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

Topics

• Adipose Tissue (cytology, transplantation)
• Adult
• Facial Hemiatrophy (diagnostic imaging, pathology, surgery)
• Female
• Graft Survival
• Humans
• Male
• Radiography
• Stromal Cells (transplantation)
• Time Factors
• Treatment Outcome
• Young Adult