Abstract | BACKGROUND:
Vitamin D has an important regulatory effect on the renin-angiotensin-aldosterone system, playing a central role in the regulation of proteinuria. We therefore studied the antiproteinuric effect of paricalcitol. METHODS: RESULTS: Mean proteinuria was 2806 mg/d and fell to 2199 mg/ d at month 6 (p<.0001) and 1931.5 mg/ d at month 12 (P<.0001). Patients with >3000 mg/d baseline proteinuria (n=12) saw smaller relative reductions in proteinuria (5956.9±2492.6 mg/d to 4220.4±2613 mg/ d at 12 months) than patients with <3000 mg/d baseline proteinuria (1371±627.5 mg/d to 821.3±491.5mg/ d at 12 months). There were no changes in BP, eGFR and CRP. We observed significant changes in serum levels of calcium, phosphorus, iPTH, 25( OH) vitamin D. CONCLUSION:
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Authors | Alberto de Lorenzo, Laura Salanova, Andrew S Bomback, María Moya, Francisco Coronel, Carmen Bernis, José A Sánchez-Tomero, Vicente Álvarez |
Journal | Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
(Nefrologia)
Vol. 33
Issue 5
Pg. 709-15
( 2013)
ISSN: 1989-2284 [Electronic] Spain |
PMID | 24089163
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin-Converting Enzyme Inhibitors
- Ergocalciferols
- Parathyroid Hormone
- Vitamin D
- Phosphorus
- paricalcitol
- C-Reactive Protein
- 25-hydroxyvitamin D
- Creatinine
- Calcium
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Topics |
- Aged
- Aged, 80 and over
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Blood Pressure
(drug effects)
- C-Reactive Protein
(analysis)
- Calcium
(blood)
- Chronic Disease
- Creatinine
(blood)
- Ergocalciferols
(administration & dosage, therapeutic use)
- Female
- Follow-Up Studies
- Glomerular Filtration Rate
(drug effects)
- Humans
- Kidney Diseases
(blood, complications, drug therapy, urine)
- Male
- Middle Aged
- Parathyroid Hormone
(blood)
- Phosphorus
(blood)
- Proteinuria
(etiology, prevention & control)
- Treatment Outcome
- Vitamin D
(analogs & derivatives, blood)
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