Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration.

Abstract

BACKGROUND:

Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood.

RESULTS:

Using linear mixed effects models, we investigated the relationship between CSF levels of heart fatty acid binding protein (HFABP), a lipid binding protein involved with fatty acid metabolism and lipid transport, amyloid-β (Aβ), phospho-tau, and longitudinal MRI-based measures of brain atrophy among 295 non-demented and demented older individuals. Across all participants, we found a significant association of CSF HFABP with longitudinal atrophy of the entorhinal cortex and other AD-vulnerable neuroanatomic regions. However, we found that the relationship between CSF HABP and brain atrophy was significant only among those with low CSF Aβ1-42 and occurred irrespective of phospho-tau181p status.

CONCLUSIONS:

Our findings indicate that Aβ-associated volume loss occurs in the presence of elevated HFABP irrespective of phospho-tau. This implicates a potentially important role for fatty acid binding proteins in Alzheimer's disease neurodegeneration.

• Authors: Rahul S Desikan, Wesley K Thompson, Dominic Holland, Christopher P Hess, James B Brewer, Henrik Zetterberg, Kaj Blennow, Ole A Andreassen, Linda K McEvoy, Bradley T Hyman, Anders M Dale, Alzheimer’s Disease Neuroimaging Initiative
• Journal: Molecular neurodegeneration (Mol Neurodegener) Vol. 8 Pg. 39 (Oct 02 2013) ISSN: 1750-1326 [Electronic] England
• PMID: 24088526 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• FABP3 protein, human
• Fatty Acid Binding Protein 3
• Fatty Acid-Binding Proteins
• tau Proteins

Topics

• Alzheimer Disease (cerebrospinal fluid, pathology)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Atrophy
• Brain (pathology)
• Fatty Acid Binding Protein 3
• Fatty Acid-Binding Proteins (cerebrospinal fluid)
• Humans
• Magnetic Resonance Imaging
• Nerve Degeneration (metabolism, pathology)
• tau Proteins (metabolism)