Abstract |
Thirty-three Israeli patients with systemic lupus erythematosus (SLE) were studied for their ability to respond to the synthetic polypeptide poly (Tyr,Glu)-poly (DLAla)-poly(Lys) [( T,G]-A-L) as measured by the production of a T cell helper factor by their antigen activated T cells. Twenty-seven of the patients were typed for their HLA phenotypes. Nineteen patients were with more active disease and 14 with a milder non-active disease. All the patients of the two groups responded to ( T,G)-A-L by the production of an antigen specific helper T cell factor, in contrast to only 50% responders among healthy donors. Thus, lack of normal regulation of T cell helper function was observed among all patients with SLE, independently of their disease activity and/or treatment. A higher frequency of DR5 (75%) was observed in patients with a milder non-active disease (vs 46.6% in normal healthy control individuals) while 53.3% of patients with active disease possessed DR7 (21.8% in controls). These findings may suggest a possible association between the severity of the disease and a specific DR determinant.
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Authors | Y Shalev, Z Bentwich, D Katz, C Brautbar, E Mozes |
Journal | Clinical and experimental immunology
(Clin Exp Immunol)
Vol. 60
Issue 2
Pg. 355-62
(May 1985)
ISSN: 0009-9104 [Print] England |
PMID | 2408803
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Epitopes
- HLA Antigens
- HLA-DR Antigens
- HLA-DR5 Antigen
- HLA-DR7 Antigen
- Histocompatibility Antigens Class II
- Interleukin-2
- Peptides
- (T,G)-A-L
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Topics |
- Antibody Formation
- Epitopes
- HLA Antigens
(analysis)
- HLA-DR Antigens
- HLA-DR5 Antigen
- HLA-DR7 Antigen
- Histocompatibility Antigens Class II
(analysis)
- Humans
- Interleukin-2
(biosynthesis)
- Lupus Erythematosus, Systemic
(immunology)
- Peptides
(immunology)
- T-Lymphocytes, Helper-Inducer
(immunology)
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