Abstract | OBJECTIVE: METHODS: Comparative analysis of exposure (HER treatment) during pregnancy in the mothers of cases with congenital abnormalities and matched control newborns without any defect in the population-based Hungarian Case-Control Surveillance System of Congenital Abnormalities. RESULTS: Of the 22,843 cases with congenital abnormalities, 567 (2.5%) had mothers with HER treatment while of 38,151 matched controls, 1143 (3.0%) were born to mothers with HER treatment (OR with 95% CI: 0.8, 0.7-0.9). However, an association of HER treatment during the second and/or third month of pregnancy was found with the higher risk of unilateral ocular coloboma (OR with 95% CI: 5.4, 2.2-12.9) and a new congenital abnormality syndrome including anotia/ microtia, poly/ syndactyly and caudal (genital and anal) defects (OR with 95% CI: 3.0, 1.3-27.4). CONCLUSIONS:
|
Authors | Eva Pósfai, Ferenc Bánhidy, Andrew E Czeizel |
Journal | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
(J Matern Fetal Neonatal Med)
Vol. 27
Issue 11
Pg. 1093-8
(Jul 2014)
ISSN: 1476-4954 [Electronic] England |
PMID | 24087950
(Publication Type: Journal Article)
|
Chemical References |
- Flavonoids
- Hydroxyethylrutoside
- Teratogens
|
Topics |
- Abnormalities, Drug-Induced
(epidemiology)
- Adolescent
- Adult
- Case-Control Studies
- Female
- Flavonoids
(toxicity)
- Humans
- Hungary
(epidemiology)
- Hydroxyethylrutoside
(toxicity)
- Pregnancy
- Teratogens
(toxicity)
- Young Adult
|