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Protective effect of p-cymene on lipopolysaccharide-induced acute lung injury in mice.

Abstract
In the previous study, the anti-inflammatory effect of p-cymene had been found. In this study, we investigated anti-inflammatory effects of p-cymene on acute lung injury using lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. The cell counting in the bronchoalveolar lavage fluid (BALF) was measured. The animal lung edema degree was evaluated by wet/dry weight (W/D) ratio. The superoxidase dismutase (SOD) activity and myeloperoxidase (MPO) activity was assayed by SOD and MPO kits, respectively. The levels of inflammatory mediators including tumor necrosis factor alpha (TNF-α), IL-1β, and IL-6 were assayed by enzyme-linked immunosorbent assay method. The pathological changes of the lung tissues were observed by hematoxylin and eosin staining. The inflammatory signal pathway-related protein levels of NF-κB were measured using Western blotting. The data showed that treatment with the p-cymene markedly attenuated inflammatory cell numbers in the BALF, decreased NF-κB protein level in the lungs, improved SOD activity, and inhibited MPO activity. Histological studies demonstrated that p-cymene substantially inhibited LPS-induced neutrophils in the lung tissue compared with the model group. The results indicated that p-cymene had a protective effect on LPS-induced ALI in mice.
AuthorsLvyi Chen, Lei Zhao, Chunfeng Zhang, Zhou Lan
JournalInflammation (Inflammation) Vol. 37 Issue 2 Pg. 358-64 (Apr 2014) ISSN: 1573-2576 [Electronic] United States
PMID24085645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Cymenes
  • Inflammation Mediators
  • Interleukin-1beta
  • Interleukin-6
  • Lipopolysaccharides
  • Monoterpenes
  • Rela protein, mouse
  • Transcription Factor RelA
  • Tumor Necrosis Factor-alpha
  • interleukin-6, mouse
  • 4-cymene
  • Peroxidase
  • Superoxide Dismutase
Topics
  • Acute Lung Injury (chemically induced, immunology, metabolism, prevention & control)
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Bronchoalveolar Lavage Fluid (immunology)
  • Cymenes
  • Cytoprotection
  • Disease Models, Animal
  • Female
  • Inflammation Mediators (metabolism)
  • Interleukin-1beta (metabolism)
  • Interleukin-6 (metabolism)
  • Lipopolysaccharides
  • Lung (drug effects, immunology, metabolism)
  • Mice
  • Mice, Inbred BALB C
  • Monoterpenes (pharmacology)
  • Neutrophil Infiltration (drug effects)
  • Peroxidase (metabolism)
  • Pulmonary Edema (chemically induced, prevention & control)
  • Superoxide Dismutase (metabolism)
  • Transcription Factor RelA (metabolism)
  • Tumor Necrosis Factor-alpha (metabolism)

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