Abstract | OBJECTIVE: METHODS: Guinea pigs were exposed to CS for 8 weeks. At the 7th and 8th week, the animals were treated with vehicle, CP (4.8 mg/kg), moguisteine (24 mg/kg), LVDP (14 mg/kg) and naringin (18.4 mg/kg) respectively. Then the cough and the time-enhanced pause area under the curve (Penh-AUC) during capsaicin challenge were recorded. The substance P (SP) content, NK-1 receptor expression and neutral endopeptidase (NEP) activity in lung were determined. RESULTS: Chronic CS exposure induced a bi-phase time course of cough responsiveness to capsaicin. Eight weeks of CS exposure significantly enhanced the airway neurogenic inflammation and cough response in guinea pigs. Two weeks of treatment with CP, moguisteine, LVDP or naringin effectively attenuated the chronic CS-exposure enhanced cough. Only naringin exerted significant effect on inhibiting Penh-AUC, SP content and NK-1 receptor expression, as well as preventing the declining of NEP activity in lung. CONCLUSIONS:
|
Authors | Yu-long Luo, Pei-bo Li, Chen-chen Zhang, Yan-fang Zheng, Sheng Wang, Yi-chu Nie, Ke-jian Zhang, Wei-wei Su |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 62
Issue 12
Pg. 1053-61
(Dec 2013)
ISSN: 1420-908X [Electronic] Switzerland |
PMID | 24085318
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antitussive Agents
- Flavanones
- Propylene Glycols
- Receptors, Neurokinin-1
- Smoke
- Thiazolidines
- Substance P
- moguisteine
- Neprilysin
- naringin
- Capsaicin
- dipropizine
- Codeine
|
Topics |
- Animals
- Antitussive Agents
(pharmacology)
- Capsaicin
- Codeine
(pharmacology)
- Cough
(chemically induced, metabolism)
- Female
- Flavanones
(pharmacology)
- Guinea Pigs
- Lung
(drug effects, metabolism)
- Male
- Neprilysin
(metabolism)
- Neurogenic Inflammation
(chemically induced, metabolism)
- Propylene Glycols
(pharmacology)
- Receptors, Neurokinin-1
(metabolism)
- Smoke
- Substance P
(metabolism)
- Thiazolidines
(pharmacology)
- Tobacco
|