Abstract | BACKGROUND: MATERIALS AND METHODS: Fifty-four ovariectomized Wistar rats were divided into seven groups. Groups 1-3 received different doses of FEO (250, 500, and 1000 mg/kg/day, respectively) for 10 days. Group 4 received saline for 10 days plus single dose of CDDP (7 mg/kg, intraperitoneally (ip)) at day 3. Groups 5-7 received FEO similar to groups 1-3, respectively; plus a single dose of CDDP (7 mg/kg, ip) on day 3. On day 10, the animals were sacrificed for histopathological studies. RESULTS: The serum levels of blood urea nitrogen (BUN) and creatinine (Cr), kidney tissue damage score (KTDS), and kidney weight (KW) and body weight changes in CDDP-treated groups increased significantly (P < 0.05). FEO did not reduce the levels of BUN and Cr, KTDS, and KW and body weight changes. Also, the serum and tissue levels of nitrite were not altered significantly by FEO. CONCLUSION: FEO, as a source of phytoestrogen, did not induce kidney damage. In addition, FEO similar to estrogen was not a nephroprotectant agent against CDDP-induced nephrotoxicity.
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Authors | Safoora Mazaheri, Mehdi Nematbakhsh, Mehrnoosh Bahadorani, Zahra Pezeshki, Ardeshir Talebi, Ali-Reza Ghannadi, Farzaneh Ashrafi |
Journal | Toxicology international
(Toxicol Int)
Vol. 20
Issue 2
Pg. 138-45
(May 2013)
ISSN: 0971-6580 [Print] India |
PMID | 24082507
(Publication Type: Journal Article)
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