Abstract | INTRODUCTION: METHODS: We have encountered three cases of pancreatoblastoma in adults at our institution in addition to the 30 cases reported to date in literature. RESULTS: The median age of pancreatoblastoma in adults is 37 years (range, 18-78 years); men and women are similarly affected (male/female = 16/17). The behavior of pancreatoblastoma is clearly that of a malignant neoplasm, with local invasion, recurrence, and metastasis. Among the adult reported cases, at diagnosis or operation, metastasis and/or local invasion was found in 14 of 31 adult patients (46 %) (2 patients had no data) The survival was significantly higher in patients with resected tumor (resection only and resection + adjuvant chemo/ radiotherapy) when compared to unresected patients (palliative chemo/ radiotherapy and no treatment), (p = 0.008, HR = 0.20). CONCLUSION: When disease is localized, the treatment of choice is a complete surgical resection. The role of adjuvant chemotherapy or radiotherapy is still unclear based on the very small number of patients treated.
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Authors | Bulent Salman, Gabriel Brat, Yoo-Seok Yoon, Ralph H Hruban, Aatur D Singhi, Elliot K Fishman, Joseph M Herman, Christopher L Wolfgang |
Journal | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
(J Gastrointest Surg)
Vol. 17
Issue 12
Pg. 2153-61
(Dec 2013)
ISSN: 1873-4626 [Electronic] United States |
PMID | 24081396
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Adolescent
- Adult
- Aged
- Chemotherapy, Adjuvant
- Fatal Outcome
- Female
- Humans
- Liver Neoplasms
(drug therapy, secondary)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Pancreatic Neoplasms
(diagnosis, mortality, pathology, surgery)
- Radiotherapy, Adjuvant
- Young Adult
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