Cytosolic HMGB1 expression in human renal clear cell cancer indicates higher pathological T classifications and tumor grades.

Abstract

PURPOSE:

High mobility group box (HMGB) proteins are nuclear nonhistone chromosomal proteins that bend DNA, bind preferentially to distorted DNA structures, and promote the assembly of site-specific DNA binding proteins. Recent reports indicate that HMGB1 functions as a proinflammatory cytokine. Here, we studied expressions of HMGB1 and HMGB2 in human renal cancer.

MATERIAL AND METHODS:

Immunohistological expressions of HMGB1 and HMGB2 were assessed in 39 surgically resected human renal cancer specimens.

RESULTS:

HMGB1 was expressed in the nucleus in 37 out of 39 (94.9%) renal clear cell cancers,while its expression in the cytosol was noted in 19 cases (48.7%). Cytosolic HMGB1 is expressed more frequently in cancers beyond the pT1b classification than in those at the pT1a classification. Higher tumor grades (≥ G2) were also significantly linked with the cytosolic expression of HMGB1. HMGB2 was expressed in the nucleus in 35 of 39 (89.7%) renal clear cell cancers, while its expression in the cytosol was observed in only 7 case (17.9%). Linkage between cytosolic expression of HMGB2 and T classifications was weakly observed, while that between nuclear expression and T classifications was not.

CONCLUSION:

HMGB1 expressed in the cytoplasm may be an effective marker indicating higher T classifications and tumor grades.

• Authors: Takumi Takeuchi, Koichi Sakazume, Akiko Tonooka, Masayoshi Zaitsu, Yuta Takeshima, Koji Mikami, Toshimasa Uekusa
• Journal: Urology journal (Urol J) Vol. 10 Issue 3 Pg. 960-5 (Sep 26 2013) ISSN: 1735-546X [Electronic] Iran
• PMID: 24078503 (Publication Type: Journal Article)

Chemical References

• HMGB1 Protein
• HMGB2 Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Renal Cell (classification, metabolism, pathology)
• Cytosol (metabolism)
• Female
• HMGB1 Protein (biosynthesis)
• HMGB2 Protein (biosynthesis)
• Humans
• Kidney Neoplasms (classification, metabolism, pathology)
• Male
• Middle Aged
• Neoplasm Grading