Carboxymethyl cellulose wafers containing antimicrobials: a modern drug delivery system for wound infections.

Abstract

Lyophilised wafers have been shown to have potential as a modern dressing for mucosal wound healing. The wafer absorbs wound exudates and transforms into a gel, thus providing a moist environment which is essential for wound healing. The objective of this study was to develop a carboxymethyl cellulose wafer containing antimicrobials to promote wound healing and treat wound infection. The pre-formulation studies began with four polymers, sodium carboxymethyl cellulose (NaCMC), methylcellulose (MC), sodium alginate and xanthan gum, but only NaCMC and MC were chosen for further investigation. The wafers were characterised by physical assessments, solvent loss, microscopic examination, swelling and hydration properties, drug content uniformity, drug release and efficacy of antimicrobials. Three of the antimicrobials, neomycin trisulphate salt hydrate, sulphacetamide sodium and silver nitrate, were selected as model drugs. Among the formulations, NaCMC wafer containing neomycin trisulphate exhibited the most desirable wound dressing characteristics (i.e., flexibility, sponginess, uniform wafer texture, high content drug uniformity) with the highest in vitro drug release and the greatest inhibition against both Gram positive and Gram negative bacteria. In conclusion, we successfully developed a NaCMC lyophilised wafer containing antimicrobials, and this formulation has potential for use in mucosal wounds infected with bacteria.

• Authors: Shiow-Fern Ng, Nafisah Jumaat
• Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (Eur J Pharm Sci) Vol. 51 Pg. 173-9 (Jan 23 2014) ISSN: 1879-0720 [Electronic] Netherlands
• PMID: 24076463 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Alginates
• Anti-Infective Agents
• Hexuronic Acids
• Polysaccharides, Bacterial
• Glucuronic Acid
• Methylcellulose
• Carboxymethylcellulose Sodium
• xanthan gum

Topics

• Alginates (chemistry)
• Anti-Infective Agents (chemistry, pharmacology)
• Carboxymethylcellulose Sodium (chemistry)
• Chemistry, Pharmaceutical (methods)
• Drug Delivery Systems (methods)
• Glucuronic Acid (chemistry)
• Hexuronic Acids (chemistry)
• Methylcellulose (chemistry)
• Polysaccharides, Bacterial (chemistry)
• Wound Healing (drug effects)
• Wound Infection (drug therapy, microbiology)