Serum and cerebrospinal fluid levels of visinin-like protein-1 in acute encephalopathy with biphasic seizures and late reduced diffusion.

Abstract

BACKGROUND:

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) has recently been recognized as an encephalopathy subtype. Typical clinical symptoms of AESD are biphasic seizures, and MRI findings show reduced subcortical diffusion during clustering seizures with unconsciousness after the acute phase. Visinin-like protein-1 (VILIP-1) is a recently discovered protein that is abundant in the central nervous system, and some reports have shown that VILIP-1 may be a prognostic biomarker of conditions such as Alzheimer's disease, stroke, and brain injury.

METHODS:

However, there have been no reports regarding serum and cerebrospinal fluid (CSF) levels of VILIP-1 in patients with AESD. We measured the serum and CSF levels of VILIP-1 in patients with AESD, and compared the levels to those in patients with prolonged febrile seizures (FS).

RESULTS:

Both serum and CSF levels of VILIP-1 were significantly higher in patients with AESD than in patients with prolonged FS. Serum and CSF VILIP-1 levels were normal on day 1 of AESD.

CONCLUSIONS:

Our results suggest that both serum and CSF levels of VILIP-1 may be one of predictive markers of AESD.

• Authors: Shunji Hasegawa, Takeshi Matsushige, Hirofumi Inoue, Midori Takahara, Madoka Kajimoto, Hiroshi Momonaka, Momoko Oka, Hiroshi Isumi, Sakie Emi, Megumi Hayashi, Takashi Ichiyama
• Journal: Brain & development (Brain Dev) Vol. 36 Issue 7 Pg. 608-12 (Aug 2014) ISSN: 1872-7131 [Electronic] Netherlands
• PMID: 24075506 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Neurocalcin
• VSNL1 protein, human

Topics

• Biomarkers (blood, cerebrospinal fluid)
• Brain Diseases (blood, cerebrospinal fluid, metabolism)
• Child, Preschool
• Female
• Humans
• Infant
• Male
• Neurocalcin (blood, cerebrospinal fluid, metabolism)
• Seizures (blood, cerebrospinal fluid, metabolism)