MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia.

Abstract	Acute myeloid leukemia (AML) is a heterogeneous disease, and optimal treatment varies according to cytogenetic risk factors and molecular markers. Several studies have demonstrated the prognostic importance of microRNAs (miRNAs) in AML. Here we report a potential association between miRNA expression and clinical outcome in 238 intermediate-risk cytogenetic AML (IR-AML) patients from 16 institutions in the CETLAM cooperative group. We first profiled 670 miRNAs in a subset of 85 IR-AML patients from a single institution and identified 10 outcome-related miRNAs. We then validated these 10 miRNAs by individual assays in the total cohort and confirmed the prognostic impact of 4 miRNAs. High levels of miR-196b and miR-644 were independently associated with shorter overall survival, and low levels of miR-135a and miR-409-3p with a higher risk of relapse. Interestingly, miR-135a and miR-409-3p maintained their independent prognostic value within the unfavorable molecular subcategory (wild-type NPM1 and CEBPA and/or FLT3-ITD), and miR-644 retained its value within the favorable molecular subcategory. miR-409-3p, miR-135a, miR-196b and mir-644 arose as prognostic markers for IR-AML, both overall and within specific molecular subgroups.
Authors	M Díaz-Beyá, S Brunet, J Nomdedéu, R Tejero, T Díaz, M Pratcorona, M Tormo, J M Ribera, L Escoda, R Duarte, D Gallardo, I Heras, M P Queipo de Llano, J Bargay, M Monzo, J Sierra, A Navarro, J Esteve, Cooperative AML group CETLAM (Grupo Cooperativo Para el Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias)
Journal	Leukemia (Leukemia) Vol. 28 Issue 4 Pg. 804-12 (Apr 2014) ISSN: 1476-5551 [Electronic] England
PMID	24072101 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Homeodomain Proteins MicroRNAs NPM1 protein, human homeobox protein HOXA9 Nucleophosmin
Topics	Adolescent Adult Aged Female Gene Expression Regulation, Neoplastic Homeodomain Proteins (genetics) Humans Leukemia, Myeloid, Acute (genetics, mortality) Male MicroRNAs (analysis) Middle Aged Nucleophosmin Prognosis Risk

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