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Treatment innovations for metastatic breast cancer: nanoparticle albumin-bound (NAB) technology targeted to tumors.

Abstract
In spite of recent advances in the treatment of metastatic breast cancer, this disease remains essentially incurable. Anthracyclines and taxanes have been widely demonstrated to be the most active cytotoxic drugs for the treatment of breast cancer. Paclitaxel and docetaxel are both hydrophobic drugs that need to be administered with detergent-like substances as solvents. In contrast, nanoparticle albumin-bound (nab) paclitaxel uses the natural characteristics of albumin to reversibly bind paclitaxel, transport it across endothelial cells and concentrate the active ingredient within the tumor. Several trials have demonstrated that nab-paclitaxel results in superior efficacy, with more complete responses, prolonged time to recurrence and survival, than paclitaxel and docetaxel in MBC. As second-line treatment, the novel formulation has almost doubled overall response rate, increased time to progression and overall survival in comparison with paclitaxel. Due to these results, to date nab-paclitaxel stands out as a promising treatment of metastatic breast cancer.
AuthorsAna Lluch, Isabel Alvarez, Montserrat Muñoz, Miguel Ángel Seguí, Ignasi Tusquets, Laura García-Estévez
JournalCritical reviews in oncology/hematology (Crit Rev Oncol Hematol) Vol. 89 Issue 1 Pg. 62-72 (Jan 2014) ISSN: 1879-0461 [Electronic] Netherlands
PMID24071503 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2013. Published by Elsevier Ireland Ltd.
Chemical References
  • 130-nm albumin-bound paclitaxel
  • Albumins
  • Antineoplastic Agents
  • Biomarkers
  • Taxoids
  • Paclitaxel
Topics
  • Albumins (administration & dosage, adverse effects, chemistry, therapeutic use)
  • Antineoplastic Agents (administration & dosage, adverse effects, chemistry)
  • Biomarkers (metabolism)
  • Breast Neoplasms (drug therapy, pathology)
  • Drug Delivery Systems
  • Female
  • Humans
  • Nanoparticles (chemistry)
  • Nanotechnology
  • Neoplasm Metastasis
  • Paclitaxel (administration & dosage, adverse effects, therapeutic use)
  • Research
  • Taxoids (administration & dosage, therapeutic use)
  • Treatment Outcome

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