Abstract | CONTEXT: Aggressive antiplatelet strategies unquestionably cause extra hemorrhagic risks. Bleeding episodes are associated with poor outcomes including increased mortality. However, lack of uniform reporting and adjudication of bleeding events might prevent objective evaluation of the efficacy/safety profile of antithrombotic agents. OBJECTIVE: We analyzed the bleeding rates by several previously used bleeding scales (TIMI, GUSTO, ACUITY, and BARC) after cangrelor in recent head-to-head randomized, controlled clinical trials (RCTs). RESULTS: Data for meta-analyses were pooled from 3 RCTs (CHAMPION-PLATFORM, CHAMPION-PCI and CHAMPION-PHOENIX) including 25,106 patients. In addition, the bleeding risks were also assessed from the small (n=210) BRIDGE RCT. Cangrelor caused a significantly increased risk for major bleeding at 48 h according to the ACUITY scale (RR: 1.51, 95% CI: 1.32-1.72, p<0.00001); however, this impact was less prominent according to less sensitive bleeding scales (GUSTO severe: RR: 1.21, 95% CI: 0.70-2.11, p=0.49; TIMI major: RR: 1.00, 95% CI: 0.59-1.68, p=0.99). There was also an obvious trend towards an increased risk for any transfusions (RR: 1.31, 95% CI: 0.97-1.77, p=0.08) and TIMI major+minor bleeding events (RR: 1.30, 95% CI: 0.96-1.76, p=0.09). CONCLUSIONS:
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Authors | Victor L Serebruany, Daniel Aradi, Moo Hyun Kim, Dirk Sibbing |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 169
Issue 3
Pg. 225-8
(Nov 05 2013)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 24071381
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | © 2013. |
Chemical References |
- Purinergic P2Y Receptor Antagonists
- Adenosine Monophosphate
- cangrelor
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Topics |
- Adenosine Monophosphate
(administration & dosage, adverse effects, analogs & derivatives)
- Hemorrhage
(chemically induced, diagnosis, epidemiology)
- Humans
- Infusions, Intravenous
- Purinergic P2Y Receptor Antagonists
(administration & dosage, adverse effects)
- Randomized Controlled Trials as Topic
(methods)
- Risk Factors
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