Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelmintic activities against Anisakis simplex and Hymenolepis nana of yakuchinone A from Alpinia oxyphylla.

Abstract

BACKGROUND:

Alpinia oxyphylla is a common remedy in traditional Chinese medicine. Yakuchinone A is a major constituent of A. oxyphylla and exhibits anti-inflammatory, antitumor, antibacterial, and gastric protective activities.

METHODS:

Antioxidant and antitumor characteristics of yakuchinone A in skin cancer cells as well as novel mechanisms for the inhibition of adipocyte differentiation, cestocidal activities against Hymenolepis nana adults, and nematocidal activities against Anisakis simplex larvae are investigated.

RESULTS:

Yakuchinone A presents the ability of the removal of DPPH·and ABTS+ free radicals and inhibition of lipid peroxidation. Yakuchinone A suppresses intracellular lipid accumulation during adipocyte differentiation in 3 T3-L1 cells and the expressions of leptin and peroxisome proliferator-activated receptor γ (PPARγ). Yakuchinone A induces apoptosis and inhibits cell proliferation in skin cancer cells. The inhibition of cell growth by yakuchinone A is more significant for non-melanoma skin cancer (NMSC) cells than for melanoma (A375 and B16) and noncancerous (HaCaT and BNLCL2) cells. Treatment BCC cells with yakuchinone A shows down-regulation of Bcl-2, up-regulation of Bax, and an increase in cleavage poly (ADP-ribose) polymerase (PARP). This suggests that yakuchinone A induces BCC cells apoptosis through the Bcl-2-mediated signaling pathway. The anthelmintic activities of yakuchinone A for A. simplex are better than for H. nana.

CONCLUSIONS:

In this work, yakuchinone A exhibits antioxidative properties, anti-adipocyte differentiation, antitumor activity, and anthelmintic activities against A. simplex and H. nana.

• Authors: Rong-Jyh Lin, Chuan-Min Yen, Tzung-Han Chou, Feng-Yu Chiang, Guey-Horng Wang, Ya-Ping Tseng, Lin Wang, Ting-Wei Huang, Hui-Chuan Wang, Leong-Perng Chan, Hsiou-Yu Ding, Chia-Hua Liang
• Journal: BMC complementary and alternative medicine (BMC Complement Altern Med) Vol. 13 Pg. 237 (Sep 26 2013) ISSN: 1472-6882 [Electronic] England
• PMID: 24070160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Antioxidants
• Plant Extracts
• Guaiacol
• yakuchinone-A

Topics

• Adipocytes (cytology, drug effects)
• Adipogenesis (drug effects)
• Alpinia (chemistry)
• Animals
• Anisakis (drug effects)
• Anthelmintics (chemistry, pharmacology)
• Antioxidants (chemistry, pharmacology)
• Apoptosis (drug effects)
• Cell Differentiation (drug effects)
• Cell Line
• Cell Survival (drug effects)
• Guaiacol (analogs & derivatives, chemistry, pharmacology)
• Humans
• Hymenolepis nana (drug effects)
• Larva (drug effects)
• Plant Extracts (chemistry, pharmacology)
• Signal Transduction (drug effects)